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3 edition of Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity found in the catalog.

Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity

Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity

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Published by National Aeronautics and Space Administration in [Washington, D.C .
Written in English

    Subjects:
  • Musculoskeletal system.,
  • Hindlimb -- Research.,
  • Gravity -- Physiological effect.,
  • Muscular atrophy.

  • Edition Notes

    Other titlesJournal of applied physiology 0161-7567.
    StatementKerry S. McDonald and Robert H. Fitts.
    Series[NASA contractor report] -- NASA CR-204850.
    ContributionsFitts, R. H., United States. National Aeronautics and Space Administration.
    The Physical Object
    FormatMicroform
    Paginationp. 1796-1802
    Number of Pages1802
    ID Numbers
    Open LibraryOL15502504M

    Nemirovskaya The effect of calpain inhibition on C.L. signaling pathways in under hindlimb unloading of rats. 5 66 Barton E.R. Masticatory muscles do not undergo atrophy in space. 23 75 Reggiani C. 6 66 Bastide B. Effects of a 21 day Bed Rest on the PI3/ AKT pathway: role of O-GlcNAc. Tendons are tough bands of connective tissue made up mostly of a protein called collagen. They do not stretch. Tendons attach each end of a muscle to a bone. They are located within sheaths that allow them to move easily. Ligaments are also tough cords formed of connective tissue, but unlike tendons they can stretch to some extent. Ligaments surround joints and help to support and stabilize them. Mechanical and structural properties of bone in non-critical and critical healing in ratq Rebecca M. Hoertha,b, Britta M. Seidta, Miheer Shaha, Carolin Schwarzb,c, Bettina M. Williec, Georg N. Dudac, Peter Fratzla, Wolfgang Wagermaiera,⇑ a Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Research Campus Golm, Potsdam, Germany. Calcium is one of the most common minerals in the human body, and 99 percent of the calcium in your body is stored in your bones and teeth, according to the Office of Dietary Supplements. Calcium serves several vital functions within your body. It plays a role in nerve conduction, constriction and relaxation of blood vessels, and hormone secretion.

    linity of the ceramic The effect of various HA/β-TCP ratios on bone fusion have been studied, especially in calvarial bone defect, and maxillary bony sinus Lim, et al reported that The Influences of Different Ratios of Biphasic Calcium Phosphate and Collagen Augmentation on Posterior Lumbar Spinal Fusion in Rat Model.


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Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity Download PDF EPUB FB2

Get this from a library. Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity. [Kerry S McDonald; R H Fitts; United States. National Aeronautics and Space Administration.].

In this work we studied changes in passive elastic properties of rat soleus muscle fibers subjected to 14 days of hindlimb unloading (HU). For this purpose, we investigated the titin isoform. We here found that MFI in intrafusal fibers of soleus muscle in rats increased significantly after the short-term (3 d) hindlimb unloading, directly suggesting an increased amount of resting intracellular calcium.

After the 7-d hindlimb unloading, decreased buffer action to high calcium of CaBP might be related to the decrease in expression of Cited by: 8. Typical recordings from a ramp and hold stretch imposed to the rat soleus muscle with the Achilles tendon severed for the control and hindlimb unloading (HU) populations.

In these examples, the stretch had amplitude of 2 mm, was maintained for s and had a velocity of 50 mm/s. (a) Displacement tracings. (b) Passive by: 9. Effect of hindlimb unloading on resting intracellular calcium in intrafusal fibers and ramp-and-hold stretches evoked responsiveness of soleus muscle spindles in conscious rats.

Effect of hindlimb unloading on resting intracellular calcium in intrafusal fibers and ramp-and-hold stretches evoked responsiveness of soleus muscle spindles in conscious rats. Zhu Y(1), Fan X, Li X, Wu S, Zhang H, Yu by: 8. A state of disuse was produced in skeletal muscle by immobilizing both hindlimbs of the rat stiffness and calcium sensitivity book plaster of paris.

After 4 stiffness and calcium sensitivity book of immobilization, the calcium concentration increased in the three different fiber types of the immobilized hindlimb.

The non-immobilized muscle of a rat showed no significant increase in calcium concentration when other limbs of the same rat were fixed by: Effect of hindlimb suspension on the functional properties stiffness and calcium sensitivity book slow and fast soleus fibers from three strains of mice.

Stelzer JE(1), Widrick JJ. Author information: (1)Department of Exercise and Sport Science, Oregon State University, Corvallis, ORby:   Soleus muscle atrophy was induced by hindlimb suspension of rats for 3 weeks with the intention of inducing a relative increase in the percentage of fast twitch fibres and assessing modifications in muscle stiffness.

A method of dual controlled releases was used to obtain tension/extension curves and force/velocity relationships characterizing the mechanical behaviour of the by: Hindlimb unloading causes atrophy of all types of fibers in the rat soleus muscle (Ishihara et al.,). Transformation of fibers from type I to IIA and decreased oxidative enzyme activity in all types of fibers are also observed in the rat soleus muscle after hindlimb unloading.

However,data pertaining to Cited by: and blood flow in the stiffness and calcium sensitivity book gastrocnemius-plantaris-soleus a/ter hindlimb suspension, J. Appl.

Physiol. 73(3):The purpose of this study was to test the hypothesis that hindlimb suspension increases the fatigability of the soleus during intense contractile activity and determine whether theFile Size: KB.

Rats underwent hindlimb unloading for 14 days; this unloading duration has been shown to cause a significant loss of trabecular bone in Adult animals [11, 13], and this unloading period was previously used to examine bone loss in Aged rats.

Cortical and trabecular bone microstructure were assessed using micro-computed by: 4. MUSCLE FIBER TYPES AND FIBER MORPHOMETRY IN THE SOLEUS MUSCLE OF THE RAT Table 1. Muscle fiber type percentages in the rat soleus muscle.

Values given are means ± SD Sex Stiffness and calcium sensitivity book Type I Type IIA Ratio Mean SD Mean I/IIA M 5 F File Size: KB. In this work we studied changes in passive elastic properties of rat soleus muscle stiffness and calcium sensitivity book subjected to 14 days of hindlimb unloading (HU).

For this purpose, we investigated the titin isoform expression in soleus muscles, passive tension-fiber strain relationships of single fibers, and the effects of the thick filament depolymerization on passive tension by: Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats.

Tomohiro Matsumoto, Takeya Ono, Hideki Ishikura, Kazuki Control Group (CON, n=7); Joint Fixation Group (JF, n=7), Hindlimb Unloading Group (HU, n=7), Joint Fixation Plus Hindlimb Unloading Group (JF+HU, n=7).

This study was conducted for by: 1. Effect of hindlimb unloading and reloading on the soleus and plantaris muscles in diabetic rats Journal of Physical Therapy Science, Vol. 30, No. 9 The response of Cited by: The right soleus muscle was used for histology and stained with hematoxylin eosin and the left soleus muscle was used to measure the MyoD and mechano growth factor mRNA expressions.

[Result] Soleus muscle wet weights and cross-sectional areas of RL and WB were significantly greater than those of HS, although those of EX were by: 2. Specifically, whereas hindlimb unweighting resulted in a significant loss of muscle protein in both the HLU and Heat+HLU groups, this effect was significantly (PCited by: Background Fibromyalgia (FM) is a chronic musculoskeletal pain disorder, characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances, however often with unknown etiology.

According to recent reports, physical and psychological stress trigger FM. To develop new treatments for FM, experimental animal models for FM are needed to be development.

The differences in contractile force between fiber types is not simply a function of differences in cross-sectional area of the fibers. Bodine et al. (Bodine et al., ) examined the effect of fiber type on specific tension and found significant differences Scaling of muscle architecture and fiber types in the rat hindlimb Carolyn M.

Eng1. sensitivity of the skin to mechanical stimulation, epidermal thickness, peripheral nerve density in the upper dermis, and serum levels of a stress marker in a rat hindlimb suspension (HS) model.

Thirty 8-week-old male Wistar rats were randomly divided into 3. title = "Modeling short-range stiffness of feline lower hindlimb muscles", abstract = "The short-range stiffness (SRS) of skeletal muscles is a critical property for understanding muscle contributions to limb stability, since it represents a muscle's capacity to resist external perturbations before reflexes or voluntary actions can by: Main Outcome Measures: Single skeletal muscle fiber contractile properties (diameter, peak active force [P0], peak specific tension [P0/CSA], and maximal shortening velocity [V0] by fiber type) were determined from the deep portion of the lateral head of the gastrocnemius muscle (RG).Cited by: nutrients Article Balanced Diet-Fed Fat-1 Transgenic Mice Exhibit Lower Hindlimb Suspension-Induced Soleus Muscle Atrophy Gabriel Nasri Marzuca-Nassr 1,2,*, Gilson Masahiro Murata 2 ID, Amanda Roque Martins 2, Kaio Fernando Vitzel 2,3, Amanda Rabello Crisma 2, Rosângela Pavan Torres 4, Jorge Mancini-Filho 4, Jing Xuan Kang 5 and Rui Curi 2,6 1 Department of Internal Medicine, Faculty of.

Mesenchymal stem cell (MSC) differentiation is regulated in part by tissue stiffness, yet MSCs can often encounter stiffness gradients within tissues caused by pathological, e.g., myocardial infarction ∼± kPa/mm, or normal tissue variation, e.g., myocardium ∼± kPa/mm; since migration predominantly occurs through physiological rather than pathological gradients, it is not Cited by: The space environment chiefly includes microgravity and radiation, which seriously threatens the health of astronauts.

Bone loss and muscle atrophy are the two most significant changes in mammals after long-term residency in space. In this review, we summarized current understanding of the effects of microgravity and radiation on the musculoskeletal system and discussed the corresponding Cited by: 2.

Hindlimb rat suspension is considered to be the model of choice for simulating the effects of hypoactivity and weightlessness, with its use having been described in > articles (17). With respect to the skeletal system, tail suspension is an appropriate model for bone disuse studies, as shown by Bloomfield et al.

(3), who established a. A Metabolic Cage for the Hindlimb Suspended Rat J. EVANS, G. M ULENBURG, J. HARPER, T.

S KUNDBERG, M. NAVIDI, AND S. ARNAUD Ames Research Center Introduction Hindlimb suspension has been successfully used to simu-late the effects of microgravity in rats. The cage and sus-pension system developed by Holton (ref. 1) is designed. Objective—To determine the accuracy of asymmetry indices of ground reaction forces (GRF) for diagnosis of hind limb lameness in dogs.

Animals—36 healthy dogs and 13 dogs with naturally acquired cranial cruciate ligament rupture or hip dysplasia. Procedures—Lameness for affected dogs ranged from not detectable to minor and dogs trotted on an instrumented treadmill, GRF Cited by: To help clarify this issue, we determined, in chloralose-anesthetized cats, the effects on arterial pressure and heart rate of rhythmically contracting the hindlimb muscles at a frequency of 5 Hz.

In addition, we determined the effect of rhythmic contractions on the impulse activity of group III and IV muscles afferents whose activation is Cited by: statically produce a certain amount of force/torque at the ground is not straightforward.

A 3D musculoskeletal model of the cat hindlimb was created from cat cadaver measurements using Software for Interactive Musculoskeletal Systems (SIMM, Musculographics, Inc.).

Six kinematic degrees of freedom and 31 individual hindlimb muscles were modeled. This study used autologous perfused rat hindlimb model to examine the effects of a fish oil diet on skeletal muscle fatigue during an acute hypoxic challenge.

Male Wistar rats were fed a diet rich in saturated fat (SF), long chain (LC) n-6 polyunsaturated fatty acids (n-6 PUFA), or LC n-3 PUFA DHA from fish oil (FO) (8weeks). Joint stiffness is a strong indicator of joint problems and arthritis in cats.

Although all breeds are susceptible to joint disease, young pets and middle-aged male felines are at greater risk of developing a condition called polyarthritis. 1B). Consistent with previous studies, we found that unloading by HS significantly increased the expression levels of atrogin-1, MuRF1 mRNAs.

At the end of the two-week period of acupuncture treatment, significant increases in mRNA expression levels in the soleus were observed for both atrogin-1 (%, Figure 2A) and MuRF1 (%, Figure 2B). calcium in rat isolated perfused juxtamedullary nephrons.

Background. Nitric oxide is an important vasodilator released from endothelial cells by the calcium-dependent endothelial nitric oxide synthase (NOS). We considered it im-portant to investigate how shear stress/perfusion pressure in-fluenced endothelial cell calcium concentration.

During regeneration from notexin-induced skeletal muscle necrosis of rat soleus muscle, SERCA expression was shown to be regulated in an isoform-specific fashion.

In SERCA2a, the COOH-terminal stretch of SERCA2b of 49 amino acids is replaced by 4 amino acids leading to functional differences ( Cited by: Onda A, Jiao Q, Nagano Y, Akimoto T, Miyamoto T, Minamisawa S et al. Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice.

Biochemical and Biophysical Research Communications. Jul 8;(3)Cited by: This paper addressed the possible mechanisms of primary reception of a mechanical stimulus by different cells.

Data concerning the stiffness of muscle and nonmuscle cells as measured by atomic force microscopy are provided. The changes in the mechanical properties of cells that occur under changed external mechanical tension are presented, and the initial stages of mechanical signal Cited by: Data are means ± SD, re 3 (diet) 01 8 rat measures) For rat data, means in a column with superscripts without a common letter differ, P.

under the force platform. Average free-fall landing GRF data of bilateral hindlimbs were presented as folds of stand-ing force (unit: N*N-1) (Figure 1A) and calculated based on the concept of force equilibrium for a force plate, which has been described in our previous study (Lin et al., ) and in Welch’s force platform design for concurrently.

In our rat 14 day hindlimb suspension unloading study, the soleus V o pdf and correlated pdf decreased thin filament density (Riley et al. ). When the soleus fibre myofilament lattice was compacted by 5% dextran, V o slowed from to FL s −1 substantiating that increasing myofilament packing density has a profound slowing.showed no strength at days 1 and 7; after a force of about 20 Download pdf was generated after a small displacement ( to mm), which then decreased rapidly with further displacement (Fig.

1,2). In the bone defect with CaS, a lower force than cancellous bone was developed at days 1 and 7.Ebook Time course of the ebook in the soleus after 1, 2, and 7 days of hindlimb unloading (HU) in rodents.

Percentage change versus control for soleus muscle weight (relative to body weight), total RNA concentration, type I MHC pre-mRNA, and skeletal α actin pre-mRNA expression.

Asterisk (*) is for P.